Enabling Technology in Fracture Surgery: State of the Art

Three-dimensional (3D) printing and virtual modeling, using computed tomographic (CT) scans as a base for the 3D-printed model, help surgeons to visualize relevant anatomy, may provide a better understanding of fracture planes, may help to plan surgical approaches, and can possibly simulate surgical fixation options. Navigation systems create real-time 3D maps of patient anatomy intraoperatively, with most literature in orthopaedic trauma thus far demonstrating efficacy in percutaneous screw placement using preoperative imaging data or intraoperative markers. Augmented reality and virtual reality are new applications in orthopaedic trauma, with the former in particular demonstrating the potential utility in intraoperative visualization of implant placement. Use of 3D-printed metal implants has been studied in limited sample sizes thus far. However, early results have suggested that they may have good efficacy in improving intraoperative measures and postoperative outcomes.

The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings

Skeletal muscle injury and repair have been a major research focus for more than a century. Muscle injuries are defined by their cause and anatomical location and lie on a spectrum in terms of repair outcomes. From contraction-induced necrosis, which initiates regenerative myogenesis for complete restoration of tissue architecture and function to, at the other end of the spectrum, traumatic volumetric muscle loss (VML), where substantial portions (or the whole) of a muscle are lost, leaving the patient with permanent physical disability. Strain injuries are found between these two extremes and are characterised by healing with scar tissue formation and a high re-rupture rate. Across these injury types, a discriminating feature for a successful outcome is the preservation of the extracellular matrix (ECM) architecture of the muscle-tendon complex, in particular the myotendinous junction (MTJ). Numerous experimental models, imaging techniques and molecular analyses have led to a thorough understanding of how muscle stem cells interact with immune, vessel and stroma-associated cells during regenerative myogenesis. Paradoxically, treatment of muscle strain injury and VML has not improved, and regenerative engineering approaches remain a distant hope. Important issues for this field include matching the level of detail that exists for animal muscle regeneration with human data and identifying the site of tissue disruption during strain injury. We propose that a closer collaboration between cell biologists, physiologists, sports medicine practitioners and orthopaedic surgeons is required to improve patient outcomes, particularly for strain injuries and VML.

Bicondylar tibial plateau fracture dislocations with an intact anterolateral cortical Rim: Prevalence, fracture characteristics, and complications

Bicondylar tibial plateau (BTP) fracture-dislocations with an intact anterolateral (AL) cortical rim present a unique treatment challenge due to posterolateral joint impaction. The purpose of this study was to determine the prevalence of this pattern within a large cohort of bicondylar tibial plateau fractures and describe fracture characteristics and complication rates.

Influence of the fixation stability on the healing time–a numerical study of a patient-specific fracture healing process

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The healing outcome of long bone fractures is strongly influenced by the interfragmentary movement of the bone fragments. This depends on the fixation stability, the optimum value of which is still not known. The aim of this study was to simulate a patient-specific human healing process using a numerical algorithm and to retrospectively analyse the influence of the fixation stability on the healing time.